期刊论文

中文

中国公共卫生

1001-0580

2007

23

8

968-969

10.3321/j.issn:1001-0580.2007.08.030

湖南省卫生厅科研项目基金（B2005090）；

本校为第一机构

目的 研究甲基叔丁基醚(Methyl tertiary butyl ether,MTBE)对大鼠小脑皮质神经递质γ-氨基丁酸(γ-GABA)的影响,探讨MTBE对中枢神经系统的急性系作用机制.方法 54只健康成年SD大鼠,体重180～220 g,随机分为9组,腹腔注射染毒,染毒剂量分别为0,700,1 050,1 400 mg/(kg·bw).观察各染毒剂量及染毒后0.5,1,2,4,8 h时MTBE对大鼠小皮质神经递质GABA的影响.结果 MTBE对小脑皮质神经递质GABA的作用其阳性产物相对灰度值结果显示,不同剂量[700,1 050,1 400mg/(kg·bw)]MTBE染毒后小脑皮质神经递质GABA相对灰度值随着染毒剂量增加而增加,存在剂量-效应关系;MTBE对小脑皮质GABA的影响在染毒后0.5 h时GABA表...

Objective To explore the acute toxic mechanism of methyl tertiary butyl ether （MTBE）, in the cerebellar cortex by detecting the change of the neurotransmitter γ- amino - butyric acid （ GABA）. Methods 54 adult SD rats were randomly divided into control and eight experiment groups. The MTBE exposed doses were 700, 1 050, 1 400mg/（ kg· bw） and the control group was used normal saline 1 400 mg/（kg· bw）respectively injected by abdominal cavity. Then the relative grey value of GABA expression was mensurated after exposed MTBE in 0.5, 1.0, ...