Objective To study the effects of long-term manganese fumes exposure on changing content of immune function and microelements in workers. Methods Immunodiffusion method and atomic absorption spectrophotometer method were used to examine the content of the serum immunoglobulin (IgA, IgG, IgM) and microelements (Zn, Cu, Fe, Mn) in blood and manganese in the urine of 116 people with manganese fumes exposure. Results The content of serum IgG, IgM on the manganese-contact group was lower than that of the control group. The IgM and IgG had a high...