期刊论文

Study on DNA damage and simina deformity of mice induced by motorbike exhaust

中文

中国公共卫生

1001-0580

2003

19

7

858-859

10.3321/j.issn:1001-0580.2003.07.039

湖南省卫生厅科研项目基金资助 （ 9951）；

本校为第一机构

目的了解摩托车使用无铅汽油后其尾气对DNA的遗传毒性作用.方法选用40只健康昆明种成年小鼠,体重24.6g～36.3g,平均体重为(30.50±5.12)g,随机分为4组,染毒组分别将摩托车尾气吸收液按1∶2,1∶4,1∶16稀释后进行灌胃染毒,每天一次,每周5d,共计40d.测定小鼠外周血淋巴细胞DNA单链的损伤以及精子畸形率的变化.结果摩托车尾气可引起小鼠外周血淋巴细胞DNA单链断裂增加,高浓度组与对照组比较有显著性差异(P＜0.01).尾气染毒组可使成年雄性小鼠精子畸变率增高,高浓度组与对照组比较有显著性差异(P＜0.05).结论摩托车使用无铅汽油其尾气对实验小鼠具有明显的遗传毒性作用.

Objective To research the DNA damage and semina deformity of motorbike exhaust using lead-free gasoline.Methods 40 mice were distributed in four groups randomly .The exposed groups were administrated by gavage with absorbent solution deluted by distilled water in 1∶2,1∶4,1∶16,one time every day for 40 days.The DNA damage in the lymphocytes of blood and semina deformity rate in mice were detected.Results The motorbike exhaust caused by using lead-free gasoline could cause DNA single strand breaks in the lymphocytes of blood.There were higher ...