期刊论文

中文

中国公共卫生

1001-0580

2003

19

12

1455-1457

10.3321/j.issn:1001-0580.2003.12.025

本校为第一机构

目的观察Balb/C小鼠吸入烹调油烟(cooking oil fumes,COF)后肺组织的病理形态改变,研究COF的慢性毒性及其致癌性.方法以Balb/C小鼠为实验对象,通过动式吸入染毒8个月(COF染毒浓度为(9.09±0.38),(20.65±0.93),(38.85±2.38)mg/m3.共染毒150次,每次染毒30min,制备COF染毒的慢性动物试验模型;对照组吸入加热空气(22～30℃).用HE染色法观察鼠肺组织病理形态改变.结果染毒组鼠肺组织病变以炎症改变为主,伴有肺泡上皮单纯性增生、腺样化生、腺瘤样增生、非典型增生和癌变,染毒组共有28例呈肺腺癌改变,另有1例为小细胞肺癌,诱癌率为18.95%.对照组仅少数有炎症改变和单纯性增生.结论 COF能诱发Balb/C小...

ObjectiveTo study the chronic toxicity of cooking oil fu mes (COF),the pathological changes of lung tissues of Balb/C mice exposed to COF were observed. MethodsBalb/C mice were used to make chronic toxicity mo del.COF groups were exposed to COF of 3 kinds of different concentration [(9.09 ±0.38),(20.65±0.93),(38.85±2.38)mg/m\+3]for 150 times in eight months for 3 0?min each time.At the same time the control group inhaled heated air (22-30? ℃) for 150 times in eight months.HE stainning was used to study the pathologica l changes.ResultsThe m...