期刊论文

中文

中国公共卫生

1001-0580

1999

15

9

793-794

湖南省教委资助项目 衡阳医学院硕士研究生课题

本校为第一机构

利用吸入烹调油烟（ 浓度为４３ ±４ｍｇ／ ｍ３） 持续染毒２０ 、４０ 、６０ 天制备动物模型，通过常规 Ｈ Ｅ 染色，光学显微镜观察肺部病理形态改变。结果表明， Ｃ Ｏ Ｆ 染毒组肺组织病理形态改变以炎症改变为主，尚有肺泡上皮腺样化生，不典型腺样增生病变形成。以第三时相病变更为明显。阴性对照组有轻度间质性肺炎及轻度的上皮增生。 Ｂ（ａ） Ｐ 组肺组织炎症病变少，以鳞状上皮化生较多见。

Objective:Spranque dawley (SD) rats were exposed to subacute dose cooking oil fumes(COF) in order to observe pathological changes of lung tissues. Mathods:Rats of test group and negative group inhaled COF (43±4mg/m 3×30min/d×20,40,60d) and hot air (30min/d×20,40,60d) respectively,while positive control group was droped B(a)P into lung from trachea(12mg/kg/5d×20,40,60d).Pathological changes of lung tissues in rats were observed by microscope. Results:in the study, the following feautures were noticed:The main pathological changes of test gr...