Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Dong, Yuan;Li, Shuoshuo;Lu, Yiming;Li, Xiaoheng;Liao, Yajin;...

通讯作者：

Hou, Lin;Yuan, Zengqiang;Cheng, Jinbo

作者机构：

[Dong, Yuan; Hou, Lin] Qingdao Univ, Med Coll, Dept Biochem, Qingdao 266071, Shandong, Peoples R China.

[Li, Shuoshuo] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China.

[Li, Shuoshuo] Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China.

[Lu, Yiming] Beijing Inst Radiat Med, Beijing 100850, Peoples R China.

[Dong, Yuan; Li, Xiaoheng; Yuan, Zengqiang; Cheng, Jinbo; Yuan, ZQ] Beijing Inst Basic Med Sci, Brain Sci Ctr, 27 Taiping Rd, Beijing 100850, Peoples R China.

通讯机构：

[Hou, Lin] Q

[Yuan, ZQ; Cheng, JB] B

[Cheng, Jinbo] M

Qingdao Univ, Med Coll, Dept Biochem, Qingdao 266071, Shandong, Peoples R China.

Beijing Inst Basic Med Sci, Brain Sci Ctr, 27 Taiping Rd, Beijing 100850, Peoples R China.

语种：

英文

关键词：

Fear memory;PTSD;NLRP3 inflammasome;Neuroinflammation;Postsynaptic density

期刊：

Journal of Neuroinflammation

ISSN：

1742-2094

年：

2020

卷：

期：

页码：

1-16

DOI：

10.1186/s12974-020-01842-0

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81870839, 81630026, 81930029, 81701187]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017 M622142]; Special Fund for Post-doctoral Innovative Projects in Shandong Province of China [201703029]; Key Field Research and Development Program of Guangdong Province [2018B03033700]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Background: Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- and stress-related disorders such as posttraumatic stress disorder (PTSD) and anxiety disorder. Despite the abundant discoveries of neuroinflammation in such disorders, the underlying mechanisms still remain unclear. Method: Wild-type and Nlrp3 -/- mice were exposed to the electric foot shocks in the contextual fear memory paradigm. Three hours after the electric foot shocks, activation of the NLRP3 inflammasome was investigated thr...

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Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

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