Growth differentiation factor-15 induces expression of ATP-binding cassette transporter A1 through PI3-K/PKCζ/SP1 pathway in THP-1 macrophages

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成果类型：

期刊论文

作者：

Wu, Jian-Feng;Wang, Yan;Zhang, Min;Tang, Yan-Yan;Wang, Bo;...

通讯作者：

Zeng, Gao-Feng

作者机构：

[Wu, Jian-Feng; Zeng, Gao-Feng; Wang, Yan; Wang, Bo] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

[Wu, Jian-Feng; He, Ping-Ping; Ouyang, Xin-Ping; Zhang, Min; Lv, Yun-Cheng; Tang, Chao-Ke; Tan, Yu-Lin; Tang, Yan-Yan; Yao, Feng] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Wang, Yan] Univ South China, Affiliated Hosp 2, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Shi-Lin] Univ South China, Affiliated Hosp 2, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.

[Tang, Deng-Pei] Univ Saskatchewan, Dept Biochem, Saskatoon, SK S7H 5E5, Canada.

通讯机构：

[Zeng, Gao-Feng] U

Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;Atherosclerosis;Cholesterol efflux;GDF-15

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2014

卷：

444

期：

页码：

325-331

DOI：

10.1016/j.bbrc.2014.01.048

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China ( 81170278 , 81370377 ) and the construct program of the key discipline in Hunan province. The authors have no conflicts to disclose.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Objective The aim of this study was to determine whether ATP-binding cassette transporter A1 (ABCA1) was up-regulated by growth differentiation factor-15 (GDF-15) via the phosphoinositide 3-kinase (PI3K)/protein kinase Cζ (PKCζ)/specificity protein 1 (SP1) pathway in THP-1 macrophages. Methods and results We investigated the effects of different concentrations of GDF-15 on ABCA1 expression in THP-1 macrophages. The results showed that GDF-15 dramatically increased cholesterol efflux and decreased cellular cholesterol levels. In addition, GDF1...

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Growth differentiation factor-15 induces expression of ATP-binding cassette transporter A1 through PI3-K/PKCζ/SP1 pathway in THP-1 macrophages

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