Alteration of DNA methylation induced by PM2.5 in human bronchial epithelial cells

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成果类型：

期刊论文

作者：

Wang, Bingyu;Li, Runbing;Cai, Ying;Li, Boru;Qin, Shuangjian;...

通讯作者：

Xu, Xinyun

作者机构：

[Xu, Xinyun; Cai, Ying; Li, Runbing; Wang, Bingyu; Zheng, Kai] Shenzhen Ctr Dis Control & Prevent, Inst Environm & Hlth, Dept Environm Toxicol, 8 Longyuan Rd, Shenzhen 518055, Guangdong, Peoples R China.

[Zhang, Zhaohui; Cai, Ying; Qin, Shuangjian; Li, Runbing; Wang, Bingyu; Zheng, Kai; Li, Boru] Univ South China, Sch Publ Hlth, Dept Prevent Med, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

[Qin, Shuangjian; Xiao, Fang; Zeng, Ming; Li, Boru] Cent South Univ, Xiangya Sch Publ Hlth, Dept Hlth Toxicol, 238 Shangmayuanling Lane, Changsha 410078, Hunan, Peoples R China.

[Xu, Xinyun] Shenzhen Ctr Dis Control & Prevent, Inst Environm & Hlth, 8 Longyuan Rd, Shenzhen 518055, Guangdong, Peoples R China.

通讯机构：

[Xu, Xinyun] S

Shenzhen Ctr Dis Control & Prevent, Inst Environm & Hlth, 8 Longyuan Rd, Shenzhen 518055, Guangdong, Peoples R China.

语种：

英文

关键词：

PM2.5;human bronchial epithelial cells;DNA methylation;bioinformatics

期刊：

TOXICOLOGY RESEARCH

ISSN：

2045-452X

年：

2020

卷：

期：

页码：

552-560

DOI：

10.1093/toxres/tfaa061

基金类别：

Shenzhen Science and Technology Committee [JCYJ20190807102205480, JCYJ20170413101713324]

机构署名：

本校为其他机构

院系归属：

医学院

公共卫生学院

摘要：

This current study explored the effects of fine particulate matter (PM2.5) on deoxyribonucleic acid methylation in human bronchial epithelial cells. Human bronchial epithelial cells were exposed to PM2.5 for 24 h after which, deoxyribonucleic acid samples were extracted, and the differences between methylation sites were detected using methylation chips. Subsequent gene ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed for the differential methylation sites. Functional epigenetic modules analysis of the overall differential methylation si...

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Alteration of DNA methylation induced by PM2.5 in human bronchial epithelial cells

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