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Targeting PRAS40: a novel therapeutic strategy for human diseases

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成果类型:
期刊论文
作者:
Zhou, Qun;Tang, Shengsong;Zhang, Xianhui;Chen, Linxi
通讯作者:
Xianhui Zhang<&wdkj&>Linxi Chen
作者机构:
[Tang, Shengsong; Zhou, Qun] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua, Peoples R China.
[Zhang, Xianhui] Dongkou Peoples Hosp, Orthoped Dept, Dongkou 422300, Hunan, Peoples R China.
[Chen, Linxi] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hunan Prov Cooperat Innovat Ctr Mol Target, New Drug Study,Inst Pharm & Pharmacol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Xianhui Zhang] O
[Linxi Chen] H
Orthopedics Department, Dongkou People’s Hospital, Dongkou, China<&wdkj&>Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China
语种:
英文
关键词:
binding protein;immunoglobulin enhancer binding protein;mammalian target of rapamycin;microRNA;proline rich akt substrate of 40;protein 14 3 3;protein kinase Pim 1;serine;threonine;unclassified drug;AKT1S1 protein, human;microRNA;protein kinase B;signal transducing adaptor protein;angiogenesis;apoptosis;autophagy (cellular);bioinformatics;cardiovascular disease;cell growth;degenerative disease;diabetes mellitus;drug targeting;human;malignant neoplasm;metabolic disorder;oxidative stress;Pi3K/Akt signaling;protein interaction;protein phosphorylation;reperfusion injury;Review;animal;genetics;metabolism;molecularly targeted therapy;phosphorylation;physiology;signal transduction;Adaptor Proteins, Signal Transducing;Animals;Humans;MicroRNAs;Molecular Targeted Therapy;Phosphorylation;Proto-Oncogene Proteins c-akt;Signal Transduction
期刊:
Journal of Drug Targeting
ISSN:
1061-186X
年:
2021
卷:
29
期:
7
页码:
703-715
基金类别:
This work was supported by the grants from the Scientific research project of Hunan Education Department [No. 16C1155], Hunan Provincial Natural Science Foundation [No. 2019JJ50424] and Science and technology project cultivation plan of Hunan University of Medicine (No.19KJPY06).
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Proline-rich Akt substrate of 40 kD (PRAS40) is not only the substrate of protein kinase B (PKB/Akt), but also the binding protein of 14-3-3 protein. PRAS40 is expressed in a variety of tissues in vivo and has multiple phosphorylation sites, which its activity is closely related to phosphorylation. Studies have shown that PRAS40 is involved in regulating cell growth, cell apoptosis, oxidative stress, autophagy and angiogenesis, as well as various of signalling pathways such as mammalian target of mammalian target rapamycin (mTOR), protein kinas...

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