Apelin is endogenous ligand of APJ which is an orphan G protein-coupled receptor. Apelin/APJ has a variety of biological effects about cells. Apelin treatment can increase endothelial cell proliferation and inhibits thrombin and collagen but not ADP and TXA2-induced platelet aggregation in vitro. As for vascular smooth muscle cell（VSMC）, an integral part of the vascular wall, takes part in normal physiological processes. VSMC dysfunction is linked to the progression of various cardiovascular diseases such as atherosclerosis and hypertension. ...
