A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiong, Shujuan;Wang, Zhe;Liu, Juan;Deng, Xiangping;Xiong, Runde;...

通讯作者：

Tang, Guotao

作者机构：

[Wang, Zhe; Deng, Xiangping; Xie, Zhizhong; Liu, Juan; Lei, Xiaoyong; Xiong, Shujuan; Tang, Guotao; Xiong, Runde; Cao, Xuan] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

[Xiong, Shujuan] Peoples Hosp Yiyang, Yiyang, Peoples R China.

[Chen, Yanming] Jiuzhitang Co Ltd, Changsha, Hunan, Peoples R China.

[Tang, Guotao] Univ South China, Changsheng Rd 28, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Guotao] U

Univ South China, Changsheng Rd 28, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Co-delivery;Low toxicity;pH-sensitive;Prodrug;Tumor therapy

期刊：

Colloids and Surfaces B: Biointerfaces

ISSN：

0927-7765

年：

2019

卷：

173

页码：

346-355

DOI：

10.1016/j.colsurfb.2018.10.012

基金类别：

This work was financiallysupported by open fund project for innovation platform of universities in Hunan ( 17K082 ), the Construct Program of the Key Discipline in Hunan province and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study .

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

This work has presented a novel strategy for designing pH-sensitive TOS-H-DOX prodrug-loaded TPGS nanomicelles for co-delivery TOS and DOX to enhance tumor therapy and reduce the toxic side effects. DOX was covalently conjugated to the vitamin E succinate through hydrazone bond to produce an pH-sensitive prodrug TOS-H-DOX (amido bond as a control, TOS-A-DOX), which was responsive to the acidic environment in tumor cells, and the prodrugs were subsequently encapsulated in the core of TPGS nanomicelles via hydrophobic effects with a significant d...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问