The effect of fructose exposure on amino acid metabolism among Chinese community residents and its possible multi-omics mechanisms

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成果类型：

期刊论文

作者：

Rang, Ouyan;Qin, Xinru;Tang, Yonghong;Cao, Lin;Li, Guojuan;...

通讯作者：

Wang, M;Zhong, J

作者机构：

[Qin, Xinru; Liu, Xiaocheng; Li, Guojuan; Tang, Yonghong; Rang, Ouyan; Wang, Mu; Cao, Lin] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Clin Mass Spectrometry Lab,Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Qin, Xinru; Liu, Xiaocheng; Li, Guojuan; Tang, Yonghong; Rang, Ouyan; Wang, Mu; Cao, Lin] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Basic Med,Nucl Ind Hyg Sch, Hengyang 421001, Hunan, Peoples R China.

[Qin, Xinru] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

[Zhong, Jing; Zhong, J] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Canc Res Inst,Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhong, J ; Wang, M ] U

Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Clin Mass Spectrometry Lab,Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Basic Med,Nucl Ind Hyg Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Canc Res Inst,Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2023

卷：

期：

页码：

22704

DOI：

10.1038/s41598-023-50069-5

基金类别：

This work was supported by the Key Project of Hunan provincial science and technology innovation (No. 2020sk1012); Natural Science Foundation of Hunan Province (No. 2022JJ30547); the excellent youthful project Scientific research of Hunan Provincial Department of Education: 20B491; “4310” cultivation program of clinical medicine research of Hengyang Medical School, University of South China [HengYiFa (2021) No. 1]; Natural Science Foundation of Hunan Province (No. 2019JJ20014); National Natural Science Foundation of China (No. 81773294); Hunan Province Clinical Medical Technology Innovation Guidance Project (No. 2020SK51905).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

The consumption of fructose has increased dramaticly during the last few decades, inducing a great increase in the risk of intrahepatic lipid accumulation, hypertriglyceridemia, hyperuricemia and cancer. However, the underlying mechanism has not yet been fully elucidated. Amino acid metabolism may play an important role in the process of the diseases caused by fructose, but there is still a lack of corresponding evidence. In present study, we provide an evidence of how fructose affects amino acids metabolism in 1895 ordinary residents in Chinese community using UPLC-QqQMS based amino acid targ...

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The effect of fructose exposure on amino acid metabolism among Chinese community residents and its possible multi-omics mechanisms

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