Effects of Apelin-13 on Rat Bone Marrow-Derived Mesenchymal Stem Cell Proliferation Through the AKT/GSK3 beta/Cyclin D1 Pathway

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成果类型：

期刊论文

作者：

Li, Lanfang;Li, Lifang;He, Lu;Zhang, Zidong;Xie, Feng;...

通讯作者：

Chen, Linxi

作者机构：

[Xie, Feng; Guo, Yu; He, Lu; Li, Jian; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.

[Xiao, Jianhua] Univ South China, Dept Microbiol & Immunol, Hengyang 421001, Peoples R China.

[Zhang, Zidong] St Louis Univ, Coll Publ Hlth & Social Justice, St Louis, MO 63108 USA.

[Li, Jian] Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China.

[Li, Jian] Minist Hlth, Beijing Inst Geriatr, Beijing 100730, Peoples R China.

通讯机构：

[Chen, Linxi] U

Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Proliferation;Apelin;Bone marrow-derived mesenchymal stem cells

期刊：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS

ISSN：

1573-3149

年：

2014

卷：

期：

页码：

421-425

DOI：

10.1007/s10989-014-9404-1

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270420, 81070634]; Heng Yang Joint Funds of Hunan Provincial Natural Science Foundation of China [12JJ8013]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [14JJ3102]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

The migration and proliferation of bone marrow-derived mesenchymal stem cells (BMSC) is critical to treatment of ischemic injury. Apelin is a recently discovered vasoactive peptide, which has been demonstrated to be the endogenous ligand for the previously orphaned G protein-coupled receptor, angiotensin-like 1 receptor. Apelin has mitogenic effects on a wide variety of cell types. However, the effects of apelin on BMSC proliferation have not been evaluated. We hypothesize that the peptide apelin-13 may enhance BMSC proliferation. Rat BMSC obta...

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Effects of Apelin-13 on Rat Bone Marrow-Derived Mesenchymal Stem Cell Proliferation Through the AKT/GSK3 beta/Cyclin D1 Pathway

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