Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics

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成果类型：

期刊论文

作者：

Zhang, Tianyi;Yang, Sheng;Ge, Yiling;Wan, Xin;Zhu, Yuxin;...

通讯作者：

Liang, GY

作者机构：

[Liang, GY; Cheng, Yanping; Yin, Lihong; Pu, Yuepu; Liang, Geyu; Ge, Yiling; Zhang, Tianyi; Yang, Sheng; Zhu, Yuxin; Wan, Xin; Li, Jie; Hu, Chengyu; Gong, Saisai] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med Engn, Minist Educ, Nanjing 210009, Jiangsu, Peoples R China.

[Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.

[Chen, Zaozao] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China.

通讯机构：

[Liang, GY ] S

Southeast Univ, Sch Publ Hlth, Key Lab Environm Med Engn, Minist Educ, Nanjing 210009, Jiangsu, Peoples R China.

语种：

英文

关键词：

PS-NPs;Respiratory exposure;Cardiotoxicity;High-throughput sequencing

期刊：

Particle and Fibre Toxicology

ISSN：

1743-8977

年：

2023

卷：

期：

页码：

1-14

DOI：

10.1186/s12989-023-00557-3

基金类别：

The authors are grateful for the financial supports by the National Natural Science Foundation of China (Nos. 82173478), the Graduate Research and Innovation Projects of Jiangsu Province (KYCX23_0326), the Fundamental Research Funds for Central Universities(2242023k30020 and 2242023k30021) and the Key Research and Development Plan (Social Development) Project of Jiangsu Province (BE2023720).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

BACKGROUND: Nanoplastics (NPs) could be released into environment through the degradation of plastic products, and their content in the air cannot be ignored. To date, no studies have focused on the cardiac injury effects and underlying mechanisms induced by respiratory exposure to NPs. RESULTS: Here, we systematically investigated the cardiotoxicity of 40nm polystyrene nanoplastics (PS-NPs) in mice exposed via inhalation. Four exposure concentrations (0µg/day, 16µg/day, 40µg/day and 100µg/day) and three exposure durations (1 week, 4 weeks,...

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Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics

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