National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21874037, 21675045, 21906077]; International Scientific and Technological Cooperation Projects of China [2012DFR40480]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ5474]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [20B508]; Key R&D Program of Hunan Province [2018SK2029]
机构署名：
本校为通讯机构
院系归属：
公共卫生学院
摘要：
A simple penicillinase functionalized two-dimensional photonic crystal hydrogel (2DPPCH) biosensor was developed for colorimetric detection of penicillin G and penicillinase inhibitors. The penicillinase can specifically recognize penicillin G and catalyze it to produce penicilloic acid, which decreases the pH of the hydrogel microenvironment and shrinks the pH-sensitive hydrogel. The particle spacing decrease of the 2D photonic crystal array induced by the hydrogel shrinkage further causes a blue-shift in the diffraction wavelength. While the ...
