[Yang, Zhen; Huang, Qin; Xie, Yuanjie; Mo, Zhongcheng] Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical school, University of South China, Hengyang 421001, China
[Liu, Yannan] Nursing School, Hunan University of Medicine, Huaihua 418000, China
通讯机构：
[Mo, Z.] C
Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical school, University of South China, Hengyang, China
语种：
英文
关键词：
Ovarian follicles;lipoprotein;sterol carrier protein 2;steroidogenesis;cholesterol homeostasis;fertility.
We thank the Natural Sciences Foundation of Hunan Province (2019JJ40248), the Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City (2017KJ182), the College Students' Research Learning and Innovative Experiment Plan in University of South China (2018XJXZ163) and the Chuanshan Talents Project in University of South China.
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Cholesterol is an important substrate for the synthesis of ovarian sex hormones and has an important influence on follicular development. The cholesterol in follicular fluid is mainly derived from plasma. High-density lipoprotein (HDL) and lowdensity lipoprotein (LDL) play important roles in ovarian cholesterol transport. The knockout of related receptors in the mammalian HDL and LDL pathways results in the reduction or absence of fertility, leading us to support the importance of cholesterol homeostasis in the ovary. However, little is known a...
