Calcitonin Gene-Related Peptide-Mediated Depressor Effect and Inhibiting Vascular Hypertrophy of Rutaecarpine in Renovascular Hypertensive Rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Qin, Xu-Ping;Zeng, Si-Yu;Li, Dai;Chen, Qing-Quan;Luo, Dan;...

通讯作者：

Li, Yuan-Jian

作者机构：

[Zeng, Si-Yu; Qin, Xu-Ping] Univ S China, Dept Pharmacol, Hengyang, Peoples R China.

[Luo, Dan; Chen, Qing-Quan; Hu, Gao-Yun; Deng, Han-Wu; Li, Dai; Zhang, Zhe; Li, Yuan-Jian] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha, Peoples R China.

[Hu, Gao-Yun] Cent S Univ, Sch Pharmaceut Sci, Dept Med Chem, Changsha, Peoples R China.

[Li, Yuan-Jian] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, 110 Xiang Ya Rd, Changsha, Peoples R China.

通讯机构：

[Li, Yuan-Jian] C

Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, 110 Xiang Ya Rd, Changsha, Peoples R China.

语种：

英文

关键词：

rutaecarpine;systolic blood pressure;calcitonin gene-related peptide;mesenteric artery;hypertrophy;2-kidney 1-clip;hypertensive rats

期刊：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

ISSN：

0160-2446

年：

2007

卷：

期：

页码：

654-659

DOI：

10.1097/FJC.0b013e3181579e7e

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Calcitonin gene-related peptide (CGRP), the predominant neurotransmitter in capsaicin-sensitive sensory nerves, is a potent vasodilator and inhibits proliferation of vascular smooth muscle cells. Previous investigations have demonstrated that the hypotensive effect of rutaecarpine (Rut) is associated to stimulation of CGRP synthesis and release via activation of the vanilloid receptor subtype 1 (VR1) in the phenol-induced hypertensive rat. This study tested whether the depressor effect and inhibiting vascular hypertrophy of Rut is mediated by endogenous CGRP in 2-kidney, 1-clip (2K1C) hyperten...

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Calcitonin Gene-Related Peptide-Mediated Depressor Effect and Inhibiting Vascular Hypertrophy of Rutaecarpine in Renovascular Hypertensive Rats

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