Transcriptional inhibition of miR-486-3p by BCL6 upregulates Snail and induces epithelial-mesenchymal transition during radiation-induced pulmonary fibrosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yan, Ziyan;Ao, Xingkun;Liang, Xinxin;Chen, Zhongmin;Liu, Yuhao;...

通讯作者：

Zhou, Pingkun;Gu, YQ

作者机构：

[Zhou, Pingkun; Liu, Xiaochang; Gu, Yongqing; Wang, Ping; Zhu, Jiaojiao; Liang, Xinxin; Yan, Ziyan; Wang, Duo; Gu, YQ; Liu, Yuhao] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing, Peoples R China.

[Gu, Yongqing; Liang, Xinxin; Zhou, Shenghui; Ao, Xingkun; Gu, YQ] Univ South China, Hengyang Med Coll, Hengyang, Hunan, Peoples R China.

[Chen, Zhongmin] PLA Rocket Force Characterist Med Ctr, Beijing, Peoples R China.

[Liu, Zheng] Univ South China, Sch Publ Hlth, Hengyang, Hunan, Peoples R China.

通讯机构：

[Zhou, PK; Gu, YQ ] B

Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Beijing, Peoples R China.

Univ South China, Hengyang Med Coll, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

miR-485-3p;EMT;Snail;BCL6;Radiation-induced pulmonary fibrosis

期刊：

RESPIRATORY RESEARCH

ISSN：

1465-9921

年：

2022

卷：

期：

页码：

1-17

DOI：

10.1186/s12931-022-02024-7

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773359, 82073488, 31470827, 31870847]

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Ionizing radiation (IR) can induce pulmonary fibrosis by causing epithelial mesenchymal transition (EMT), but the exact mechanism has not been elucidated. To investigate the molecular mechanism of how radiation induces pulmonary fibrosis by altering miR-486-3p content and thus inducing EMT. The changes of miR-486-3p in cells after irradiation were detected by RT-qPCR. Western blot was used to detect the changes of cellular epithelial marker protein E-cadherin, mesenchymal marker N-cadherin, Vimentin and other proteins. The target gene of miR-48...

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Transcriptional inhibition of miR-486-3p by BCL6 upregulates Snail and induces epithelial-mesenchymal transition during radiation-induced pulmonary fibrosis

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