Creating first-class undergraduate education is an important direction of China’s college education. Green chemistry is a new requirement put forward by the contemporary society for chemical science, and should be fully applied to China’s first-class undergraduate education. In this paper, the synthesis of procaine hydrochloride in the medicinal chemistry experiment teaching is taken as an example. For the shortcomings of the current textbook, such as long time-consuming, low yield, high energy consumption and heavy pollution, the original sy...