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Neuroprotective Effect of α-Lipoic Acid against Aβ25–35-Induced Damage in BV2 Cells

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成果类型:
期刊论文
作者:
Pei, Xinrong;Hu, Fangyan;Hu, Zehui;Luo, Feiya;Li, Xiaoling;...
通讯作者:
Dingxin Long<&wdkj&>Lei Sun
作者机构:
[Pei, Xinrong; Luo, Feiya; Sun, Lei; Xing, Shuxia] Natl Inst Food & Drug Control, Beijing 100052, Peoples R China.
[Li, Xiaoling; Hu, Fangyan; Long, Dingxin; Hu, Zehui] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.
[Li, Xiaoling; Hu, Fangyan; Long, Dingxin; Hu, Zehui] Univ South China, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.
通讯机构:
[Dingxin Long; Lei Sun] A
Authors to whom correspondence should be addressed.<&wdkj&>School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>National Institutes for Food and Drug Control, Beijing 100052, China
语种:
英文
关键词:
Alzheimer's disease;alpha-lipoic acid;neurotoxicity;microglia;Wnt/beta-catenin pathway
期刊:
Molecules
ISSN:
1420-3049
年:
2023
卷:
28
期:
3
页码:
1168-
基金类别:
Conceptualization, X.P. and L.S.; methodology, X.P. and F.H.; software, F.H. and Z.H.; validation, F.L., X.L. and D.L.; formal analysis, X.P., X.L. and S.X.; investigation, X.P.; resources, L.S. and D.L.; data curation, X.P.; writing—original draft preparation, X.P. and F.H.; writing—review and editing, X.P., F.H., Z.H. and D.L.; visualization, X.P. and F.H.; supervision, L.S. and D.L.; project administration, L.S. and D.L.; funding acquisition, L.S. and D.L. All authors have read and agreed to the published version of the manuscript. This work was funded by the National Key Research and Development Program of China (2018YFC1603701) and the National Natural Science Foundation of China (81673227 and 81001246).
机构署名:
本校为其他机构
院系归属:
公共卫生学院
摘要:
The prevalence of Alzheimer's disease (AD) is significantly increasing due to the aging world population, and the currently available drug treatments cannot cure or even slow its progression. alpha-lipoic acid (LA) is a biological factor widely found in spinach and meat and can dissolve in both lipid and aqueous phases. In medicine, LA has been shown to reduce the symptoms of diabetic polyneuropathy, acute kidney injury, cancers, and some metabolism-related diseases. This study to proves that alpha-lipoic acid (LA) can stabilize the cognitive function of patients with Alzheimer's disease (AD)....

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