Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury

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成果类型：

期刊论文

作者：

Gao, Youguang;Chen, Ting;Lei, Xianghui;Li, Yunfeng;Dai, Xingui;...

通讯作者：

Lin, Xianzhong;Li, Tao

作者机构：

[Gao, Youguang; Lin, Xianzhong; Chen, Ting] Fujian Med Univ, Dept Anesthesiol, Affiliated Hosp 1, 20 Chazhong Rd, Fuzhou 350005, Fujian, Peoples R China.

[Ding, Qionglei; Li, Tao; Li, Yunfeng; Cao, Yuanyuan; Dai, Xingui; Lei, Xiabao] Univ South China, Inst Translat Med, Peoples Hosp Chenzhou 1, Dept Crit Care Med, 102 Luojiajing, Chenzhou 423000, Hunan, Peoples R China.

[Lei, Xianghui] Univ South China, Inst Translat Med, Peoples Hosp Chenzhou 1, Dept Pathol, Chenzhou 423000, Hunan, Peoples R China.

通讯机构：

[Lin, Xianzhong] F

[Li, Tao] U

Fujian Med Univ, Dept Anesthesiol, Affiliated Hosp 1, 20 Chazhong Rd, Fuzhou 350005, Fujian, Peoples R China.

Univ South China, Inst Translat Med, Peoples Hosp Chenzhou 1, Dept Crit Care Med, 102 Luojiajing, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

polydatin;ischemic stroke;oxidative stress;mitochondria;apoptosis

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2016

卷：

期：

页码：

5481-5488

DOI：

10.3892/mmr.2016.5936

基金类别：

Medical Innovation Fund of Fujian Province, China [2015-CX-22]; Finance Department of Health Special Fund of Fujian Province, China [BPB-LXZ2014]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500066]; Natural Science Foundation of Fujian ProvinceNatural Science Foundation of Fujian Province [2016J01451]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

The neuroprotective effect of polydatin (PD) against hemorrhagic shock-induced mitochondrial injury has been described previously, and mitochondrial dysfunction and apoptosis were reportedly involved in ischemic stroke. In the present study the neuroprotective effect of PD in preventing apoptosis was evaluated following induction of focal cerebral ischemia by middle cerebral artery occlusion (MCAO) in rats. PD (30 mg/kg) was administered by caudal vein injection 10 min prior to ischemia/reperfusion (I/R) injury. 24 h following I/R injury, ameliorated modified neurological severity scores (mNSS...

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Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury

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