Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways

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成果类型：

期刊论文

作者：

Chen, Wen-Lin;Niu, Ying-Ying;Jiang, Wei-Zheng;Tang, Hui-Lan;Zhang, Chong;...

通讯作者：

Tang, Xiao-Qing

作者机构：

[Chen, Wen-Lin; Tang, Hui-Lan; Jiang, Wei-Zheng; Niu, Ying-Ying; Xia, Qi-Ming; Zhang, Chong] Univ South China, Coll Med, Inst Neurosci, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ South China, Coll Med, Inst Neurosci, Hengyang, Hunan, Peoples R China.

[Chen, Wen-Lin; Tang, Hui-Lan; Jiang, Wei-Zheng; Xia, Qi-Ming; Zhang, Chong] Univ South China, Coll Med, Grade Clin Med 2009, Hengyang 421001, Hunan, Peoples R China.

[Niu, Ying-Ying] Univ South China, Coll Med, Grade Clin Med 2011, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ South China, Coll Med, Inst Neurosci, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing] U

Univ South China, Coll Med, Inst Neurosci, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

central nervous system diseases;hydrogen sulfide;neuroprotective;signaling pathways

期刊：

Reviews in the Neurosciences

ISSN：

0334-1763

年：

2015

卷：

期：

页码：

129-142

DOI：

10.1515/revneuro-2014-0051

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371485, 81200985]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [11JJ3117, 12JJ9032]; Project of Research-based Learning and Innovative Experiment for Undergraduate Student in Hunan Province [2011-199]; construct program of the key discipline in Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Hydrogen sulfide (H2S) is an endogenously produced gas that represents a novel third gaseous signaling molecule, neurotransmitter and cytoprotectant. Cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercaptopyruvate sulfur transferase with cysteine aminotransferase (3-MST/CAT) and 3-mercaptopyruvate sulfur transferase with D-amino acid oxidase (3-MST/DAO) pathways are involved in the generation of endogenous H2S despite the ubiquitous or restricted distribution of those enzymes. CBS, 3-MST/CAT and 3-MST/DAO can be found in the brain, while CSE is widely located in other or...

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Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways

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