Neuroprotective effect of asymmetric dimethylarginine against 1-methyl-4-phenylpyridinium ion-induced damage in PC12 cells

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成果类型：

期刊论文

作者：

Tang, Xiao-Qing*;Li, Yu-Juan;Zhao, Jing;Shen, Xing-Tian;Yang, Chun-Tao;...

通讯作者：

Tang, Xiao-Qing

作者机构：

[Yang, Chun-Tao; Li, Yu-Juan; Tang, Xiao-Qing; Fan, Li-Li; Zhao, Jing; Shen, Xing-Tian; Hu, Bi] Univ S China, Coll Med, Dept Physiol, Hengyang, Hunan, Peoples R China.

[Li, Yuan-Jian] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha, Hunan, Peoples R China.

[Tang, Xiao-Qing; Liao, Duan-Fan] Univ S China, Life Sci Res Ctr, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ S China, Coll Med, Dept Physiol, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing] U

Univ S China, Coll Med, Dept Physiol, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

1-methyl-4-phenylpyridinium ion;Asymmetric dimethylarginine;Neuroprotection;Nitric oxide;Nitric oxide synthase;Parkinson's disease

期刊：

Clinical and Experimental Pharmacology and Physiology

ISSN：

0305-1870

年：

2010

卷：

期：

5-6

页码：

530-535

DOI：

10.1111/j.1440-1681.2010.05344.x

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30770740]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [06JJ2074]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2005038233]

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

1. Asymmetric dimethylarginine (ADMA) is a well-known endogenous nitric oxide synthase (NOS) inhibitor. Although it has been shown to be a novel risk marker in cardiovascular medicine and chronic kidney disease, we speculated that in some states associated with excess of nitric oxide (NO), such as 1-methyl-4-phenylpyridinium ion (MPP+)-induced neuronal injury, ADMA might be protective by limiting the toxic effect of high concentrations of NO. 2. The aim of the present study is to explore the protection of ADMA against MPP+-induced apoptosis and...

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Neuroprotective effect of asymmetric dimethylarginine against 1-methyl-4-phenylpyridinium ion-induced damage in PC12 cells

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