Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C α signaling in THP-1 macrophage-derived foam cells

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成果类型：

期刊论文

作者：

Liu, Xiao-Yan;Lu, Qian;Ouyang, Xin-Ping;Tang, Shi-Lin;Zhao, Guo-Jun;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Zhao, Guo-Jun; Lv, Yun-Cheng; Tang, Chao-Ke; Lu, Qian; Liu, Xiao-Yan; He, Ping-Ping; Ouyang, Xin-Ping; Tang, Yan-Yan; Kuang, Hai-Jun; Tang, Shi-Lin] Univ S China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Kuang, Hai-Jun; Tang, Shi-Lin] Univ S China, Affiliated Hosp 1, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.

[Fu, Yuchang] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ S China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Apelin;ABCA1;PKC alpha;Calpain;Atherosclerosis

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2013

卷：

226

期：

页码：

398-407

DOI：

10.1016/j.atherosclerosis.2012.12.002

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070220, 81170278]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Province, China [2008-244]

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Apelin has an antiatherogenic function through activating protein kinase C (PKC) to initiate a series of cellular signaling pathways. PKC phosphorylates and stabilizes ATP-binding cassette transporter A1 (ABCA1) through inhibiting its degradation mediated by calpain. Thus, in the present study, we investigated whether apelin-13 affects expression of ABCA1 through PKC signaling. The results showed that apelin-13 dramatically increased cholesterol efflux from THP-1 macrophage-derived foam cells and reduced cellular cholesterol levels. ABCA1 prote...

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Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C α signaling in THP-1 macrophage-derived foam cells

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