期刊论文

Wei, Rui;Luo, JL

英文

Cancers

2072-6694

2024

16

3

597-

10.3390/cancers16030597

This research was funded by grants from the National Natural Science Foundation of China (Nos. 81974469 and 81672635), Hunan Provincial Key Program for Research and Development (No. 2018SK21214), and a grant from the Postgraduate Independent Exploration and Innovation Project of Central South University of China (No. 2020zzts256), Hunan Provincial Natural Science Foundation of China (No. 2021JJ31104), the National Science Foundation of China for Youth (No. 82203166), General Project of Hunan Provincial Health Commission Research Program (No. B202302057895).

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Simple Summary In this study, we found that high FTSJ1 expression in triple-negative breast cancer patients was associated with poor prognosis and was associated with reduced infiltration of CD8+T cells in the tumor microenvironment. By knocking down FTSJ1, we observed an inhibitory effect on the proliferation and migration of triple-negative breast cancer, while inducing apoptosis and increasing the sensitivity of TNBC cells to T-cell-mediated cytotoxicity. This finding highlights the importance of FTSJ1 as a potential immunotherapy target in triple-negative breast cancer.Abstract FtsJ RNA 2 ...