Triple-Negative Breast Cancer Intrinsic FTSJ1 Favors Tumor Progression and Attenuates CD8+ T Cell Infiltration

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成果类型：

期刊论文

作者：

Sun, Yangqing;Liu, Qingqing;Zhong, Shangwei;Wei, Rui*;Luo, Jun-Li

通讯作者：

Wei, Rui;Luo, JL

作者机构：

[Wei, Rui; Liu, Qingqing; Luo, Jun-Li; Wei, R; Sun, Yangqing; Luo, JL] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Peoples R China.

[Zhong, Shangwei; Luo, Jun-Li; Luo, JL] Univ South China, Affiliated Hosp 2, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Luo, Jun-Li; Luo, JL] Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China.

通讯机构：

[Wei, R; Luo, JL ] C

Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Peoples R China.

Univ South China, Affiliated Hosp 2, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.

Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China.

语种：

英文

关键词：

FTSJ1;tumor promotor;CD8+T cell infiltration;triple-negative breast cancer

期刊：

Cancers

ISSN：

2072-6694

年：

2024

卷：

期：

页码：

597-

DOI：

10.3390/cancers16030597

基金类别：

This research was funded by grants from the National Natural Science Foundation of China (Nos. 81974469 and 81672635), Hunan Provincial Key Program for Research and Development (No. 2018SK21214), and a grant from the Postgraduate Independent Exploration and Innovation Project of Central South University of China (No. 2020zzts256), Hunan Provincial Natural Science Foundation of China (No. 2021JJ31104), the National Science Foundation of China for Youth (No. 82203166), General Project of Hunan Provincial Health Commission Research Program (No. B202302057895).

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

FtsJ RNA 2′-O-methyltransferase 1 (FTSJ1) is a member of the methyltransferase superfamily and is involved in the processing and modification of ribosomal RNA. We herein demonstrate that FTSJ1 favors TNBC progression. The knockdown of FTSJ1 inhibits TNBC cell proliferation and development, induces apoptosis of cancer cells, and increases the sensitivity of TNBC cells to T-cell-mediated cytotoxicity. Furthermore, the high expression of FTSJ1 in TNBC attenuates CD8+T cell infiltration in the tumor microenvironment (TME) correlated with poorer pr...

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Triple-Negative Breast Cancer Intrinsic FTSJ1 Favors Tumor Progression and Attenuates CD8+ T Cell Infiltration

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