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Triple-negative breast cancer and its association with obesity

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成果类型:
期刊论文
作者:
Heng Sun;Jing Zou;Ling Chen;Xuyu Zu;Gebo Wen;...
作者机构:
[Gebo Wen; Jing Zhong; Heng Sun; Xuyu Zu; Ling Chen] Institute of Clinical Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China
[Gebo Wen; Heng Sun] Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China
[Jing Zou] Department of Neurological Medicine, Hunan Institute of Gerontology, Hunan Geriatric Hospital, Changsha, Hunan 410016, P.R. China
语种:
英文
关键词:
biological rationale;clinical issues;novel targeted therapies;obesity;prognosis;triple-negative breast cancer
期刊:
Molecular and Clinical Oncology
ISSN:
2049-9450
年:
2017
卷:
7
期:
6
页码:
935-942
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks expression of the estrogen and progesterone receptor and does not overexpress human epidermal growth factor 2 receptor protein. TNBC is associated with special characteristics, including aggressiveness, poor prognosis and poor response to treatment, and has been attracting increasing attention worldwide. Obesity is a well-documented factor exerting a significant effect on the development of breast cancer, including TNBC. The purpose of the present review was to focus on the association between obesity and TNBC and pr...

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