Intratracheal instillation of graphene oxide with different diameters suppressed toll-like receptor 3-mediated lipid droplet biogenesis in lungs and livers of mice.
Wang, Yijin;Tang, Xiaomin;Luo, Sihuan;Zhang, Zhaohui;Cao, Yi
作者机构：
[Zhang, Zhaohui; Wang, Yijin; Tang, Xiaomin; Luo, Sihuan; Cao, Yi] Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Changsheng Road No. 28, Zhengxiang District, Hengyang city, Hunan Province, Hengyang 421001, China
Recent advances have established lipid droplets as dynamic innate immune hubs coordinating cellular metabolism and defense mechanisms. While previous studies primarily focused on nanomaterials (NMs) altering lipid metabolism to influence lipid droplet dynamics, this study pioneers the investigation of NM-induced immune modulation via Toll-like receptor (TLR) pathways as a novel regulatory axis for lipid droplets. Building on our prior findings that graphene oxide (GO) impaired TLR3-mediated lipid signaling, we systematically explored the role o...
