Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Cong-hui;Gong, Duo;Chen, Ling-yan;Zhang, Min;Xia, Xiao-dan;...

通讯作者：

Tang, Chao-ke;Tang, Xiao-er

作者机构：

[Gong, Duo; Tang, Chao-ke; Zhao, Zhen-wang; Cheng, Hai-peng; Li, Cong-hui; Chen, Ling-yan; Xia, Xiao-dan; Huang, Chong; Zhang, Min] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Key Lab Atherosclerol Hunan Prov,Inst Cardiovasc, Hengyang 421001, Hunan, Peoples R China.

[Li, Cong-hui] XiangNan Univ, Affiliated Hosp, Dept Ultrasound, Chenzhou 423000, Hunan, Peoples R China.

[Tang, Xiao-er] Shaoyang Univ, Dept Pathol, Shaoyang 422000, Hunan, Peoples R China.

[Zheng, Xi-long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Libin Cardiovasc Inst Alberta,Dept Biochem & Mol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chao-ke] U

[Tang, Xiao-er] S

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Key Lab Atherosclerol Hunan Prov,Inst Cardiovasc, Hengyang 421001, Hunan, Peoples R China.

Shaoyang Univ, Dept Pathol, Shaoyang 422000, Hunan, Peoples R China.

语种：

英文

关键词：

Puerarin;ABCA1;Cholesterol efflux;Lipid accumulation

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2017

卷：

811

页码：

74-86

DOI：

10.1016/j.ejphar.2017.05.055

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (81570408).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

It was reported that puerarin decreases the total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and increases high-density lipoprotein cholesterol (HDL-C) level, but the underlying mechanism is unclear. This study was designed to determine whether puerarin decreased lipid accumulation via up-regulation of ABCA1-mediated cholesterol efflux in THP-1 macrophage-derived foam cells. Our results showed that puerarin significantly promoted the expression of ATP-binding cassette transporter A1 (ABCA1) mRNA and protein via ...

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Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages

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