Tanshinone IIA Promotes Macrophage Cholesterol Efflux and Attenuates Atherosclerosis of apoE-/- Mice by Omentin-1/ABCA1 Pathway

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成果类型：

期刊论文

作者：

Tan, Yu-lin;Ou, Han-xiao;Zhang, Min;Gong, Duo;Zhao, Zhcn-wang;...

通讯作者：

Mo, Zhong-cheng;Tang, Chao-ke

作者机构：

[Gong, Duo; Tang, Chao-ke; Tan, Yu-lin; Zhao, Zhcn-wang; Chen, Ling-yan; Xia, Xiao-dan; Zhang, Min] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Dis, Med Res Ctr,Key Lab Arterosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Tan, Yu-lin] XiangNan Univ, Inst Pathol Res, Dept Pathophysiol, Key Disciplines Immunol,Key Lab Nat Cardiovasc Me, Chenzhou 423000, Peoples R China.

[Ou, Han-xiao; Mo, Zhong-cheng] Univ South China, Cooperat Innovat Base Basic & Clin Med, Hengyang 414000, Hunan, Peoples R China.

[Ou, Han-xiao; Mo, Zhong-cheng] Yueyan Matern Child Hlth Hosp, Dept Genet & Eugen, Hengyang 414000, Hunan, Peoples R China.

[Ou, Han-xiao; Mo, Zhong-cheng] Univ South China, Sch Med, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang, Peoples R China.

通讯机构：

[Mo, ZC; Tang, CK] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Key Lab Arterosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Tan IIA;Omentin-1;ABCA1;cholesterol efflux;reverse cholesterol transport;plaque vulnerability.

期刊：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY

ISSN：

1389-2010

年：

2019

卷：

期：

页码：

422-432

DOI：

10.2174/1389201020666190404125213

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570408]; Scientific Research Innovation Program of post-graduate in Hunan Province [CX2017B554]; Hunan Provincial Natural Science Fund of China [2015JJ2131]; Medical Research Plan Projects Foundation of Hunan Provincial Health Department [B2014-070]; Cardiovascular and Cerebrovascular diseases Natural drug Research Fund Project of Key Laboratory of Universities in Hunan Province [XN2017K01]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background:Tanshinone IIA (Tan IIA) and Omentin-1 have a protective role in the cardiovascular system. However, if and how Tan IIA and Omentin-1 regulate cholesterol metabolism in macrophages has not been fully elucidated.Objective:To investigate the possible mechanisms of Tan IIA and Omentin-1 on preventing macrophage cholesterol accumulation and atherosclerosis development.Methods:The effect of Tan IIA on the protein and mRNA levels of Omentin-1 and ATP-binding cassette transporter A1 (ABCA1) in macrophages was examined by Western blot and qR...

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Tanshinone IIA Promotes Macrophage Cholesterol Efflux and Attenuates Atherosclerosis of apoE-/- Mice by Omentin-1/ABCA1 Pathway

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