beta 2-microglobulin induces depressive- and anxiety-like behaviors in rat

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Ping;Zeng, Dan;Yi, Yi-Li;Tang, Yi-Yun;Zou, Wei;...

通讯作者：

Tang, Xiao-Qing;Yang, Xue-Feng

作者机构：

[Zou, Wei; Zeng, Dan; Zhang, Ping; Yi, Yi-Li] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang, Hunan, Peoples R China.

[Wang, Chun-Yan; Tang, Xiao-Qing; Zou, Wei; Zeng, Dan; Zhang, Ping; Tang, Yi-Yun; Yi, Yi-Li] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Neurosci, Hengyang, Hunan, Peoples R China.

[Tang, Xiao-Qing; Tang, Yi-Yun] Univ South China, Med Coll, Dept Physiol, Hengyang, Hunan, Peoples R China.

[Yang, Xue-Feng] Univ South China, Affiliated Nanhua Hosp, Dept Gastroenterol, Hengyang, Hunan, Peoples R China.

[Wang, Chun-Yan] Univ South China, Med Coll, Dept Pathophysiol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Yang, Xue-Feng] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Neurosci, Hengyang, Hunan, Peoples R China.

Univ South China, Med Coll, Dept Physiol, Hengyang, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Dept Gastroenterol, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Rats;Depression;Behavior;Swimming;Hippocampal neurogenesis;Adult neurogenesis;Anxiety disorders;Major histocompatibility complex

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2018

卷：

期：

页码：

e0198027

DOI：

10.1371/journal.pone.0198027

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471310, 81771178]; Major Research Topics of the Health and Family Planning Commission of Hunan province [A2017020]; Key Projects of the Education Department of Hunan province [17A187]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

beta2-microglobulin (B2M), the light chain of major histocompatibility complex class I (MHC I) molecules, has been found to impair hippocampal neurogenesis. Based on the crucial role of hippocampal neurogenesis disturbance in the process of depression and anxiety, the aim of the present study is to investigate whether B2M leads to depressive- and anxiety-like behaviors. We found that 6 days after intracerebroventricular injection with B2M (0.3 mug), the immobility times of rats in the tail suspension test and the forced swimming test were increased, the swimming and climbing time in the forced...

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beta 2-microglobulin induces depressive- and anxiety-like behaviors in rat

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