miR-758-5p regulates cholesterol uptake via targeting the CD36 3′UTR

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Bi-Rong;Xia, Lin-Qin;Liu, Jing;Liao, Lin-Ling;Zhang, Yang;...

通讯作者：

He, Ping-Ping;Ouyang, Xin-Ping

作者机构：

[Zhang, Yang; Deng, Min; Li, Bi-Rong] Shaoyang Med Coll, Dept Physiol, Shaoyang 422000, Hunan, Peoples R China.

[He, Ping-Ping; Ouyang, Xin-Ping] Univ South China, Med Coll, Neurosci Inst, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Xia, Lin-Qin] Shaoyang Med Coll, Dept Pathol, Shaoyang 422000, Hunan, Peoples R China.

[Liu, Jing] Shaoyang Med Coll, Fac Nursing, Shaoyang 422000, Hunan, Peoples R China.

[Liao, Lin-Ling] Shaoyang Med Coll, Affiliated Hosp, Dept Hematol Oncol, Shaoyang 422000, Hunan, Peoples R China.

通讯机构：

[He, Ping-Ping; Ouyang, Xin-Ping] U

Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Med Coll, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*Atherosclerosis;*CD36;*Cholesterol uptake;*miR-758-5p

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2017

卷：

494

期：

1-2

页码：

384-389

DOI：

10.1016/j.bbrc.2017.09.150

基金类别：

The authors gratefully acknowledge the financial support from the Scientific Research Project in Hunan Province Department of Education ( 09C047 , 13C868 ), the Shaoyang Science and Technology Plan Projects ( N1228 ), the Administration of Traditional Chinese Medicine of Hunan Province ( 201524 ), the National Natural Sciences Foundation of China ( 81300158 ), the Department of Hunan Province Science and Technology Plan Projects ( 2015JC3083 ), the Zhengxiang Scholar Program of University of South China ( 2014-004 ).

机构署名：

本校为通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

miR-758-3p plays an important role via regulting ABCA1-mediated cholesterol efflux in atherosclerosis. However, the mechanism of miR-758-5p in cholesterol metabolism is still unclear. Here, we revealed that miR-758-5p decreased total cholesterol accumulation in THP-1 macrophage derived foam cells through markedly reducing cholesterol uptake, and no effect on the cholesterol efflux. Interestingly, computational analysis suggests that CD36 may be a target gene of miR-758-5p. Our study further demonstrated that miR-758-5p decreased CD36 expression...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

miR-758-5p regulates cholesterol uptake via targeting the CD36 3′UTR

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问