期刊论文

He, Ping-Ping;Ouyang, Xin-Ping

英文

Biochemical and Biophysical Research Communications

0006-291X

2017

494

1-2

384-389

10.1016/j.bbrc.2017.09.150

The authors gratefully acknowledge the financial support from the Scientific Research Project in Hunan Province Department of Education ( 09C047 , 13C868 ), the Shaoyang Science and Technology Plan Projects ( N1228 ), the Administration of Traditional Chinese Medicine of Hunan Province ( 201524 ), the National Natural Sciences Foundation of China ( 81300158 ), the Department of Hunan Province Science and Technology Plan Projects ( 2015JC3083 ), the Zhengxiang Scholar Program of University of South China ( 2014-004 ).

本校为通讯机构

miR-758-3p plays an important role via regulting ABCA1-mediated cholesterol efflux in atherosclerosis. However, the mechanism of miR-758-5p in cholesterol metabolism is still unclear. Here, we revealed that miR-758-5p decreased total cholesterol accumulation in THP-1 macrophage derived foam cells through markedly reducing cholesterol uptake, and no effect on the cholesterol efflux. Interestingly, computational analysis suggests that CD36 may be a target gene of miR-758-5p. Our study further demonstrated that miR-758-5p decreased CD36 expression at both protein and mRNA levels via targeting the...