CPNE1 mediates glycolysis and metastasis of breast cancer through activation of PI3K/AKT/HIF-1α signaling

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cao, Jingying;Cao, Renxian;Liu, Yiqi;Dai, Tao

通讯作者：

Cao, JY;Dai, T

作者机构：

[Cao, Jingying] Cent South Univ, Xiangya Hosp 3, Dept Med Clin Lab, Changsha 410013, Hunan, Peoples R China.

[Cao, Renxian] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Liu, Yiqi] Univ South China, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Dai, Tao] Cent South Univ, Xiangya Sch Med, Hunan Canc Hosp, Affiliated Canc Hosp,Dept Urol, Changsha 410013, Hunan, Peoples R China.

[Cao, Jingying; Cao, JY] Cent South Univ, Xiangya Hosp 3, Dept Med Clin Lab, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Dai, T ; Cao, JY ] C

Cent South Univ, Xiangya Hosp 3, Dept Med Clin Lab, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Xiangya Sch Med, Hunan Canc Hosp, Affiliated Canc Hosp,Dept Urol, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

AKT;CPNE1;Glycolysis;PI3K;Triple-negative breast cancer

期刊：

PATHOLOGY RESEARCH AND PRACTICE

ISSN：

0344-0338

年：

2023

卷：

248

页码：

154634

DOI：

10.1016/j.prp.2023.154634

基金类别：

National Natural Science Foundation of China Youth Fund [2021JJ40914]; Hunan Natural Science Foundation Youth Fund Project; [81903027]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

CPNE1 regulates multiple signaling pathways and can stimulate cell proliferation and differentiation by activating the AKT-mTOR signaling pathway. In addition, CPNE1 is associated with various cancers; however, its role in breast cancer, particularly in TNBC, has not been fully elucidated. Our study aimed to reveal the impact of the CPNE1/PI3K/AKT/HIF-1α axis on TNBC. We first measured the expression of CPNE1 in the tumor tissues of TNBC patients and examined its prognostic value. Subsequently, we used sh-CPNE1 and overexpression vectors to tr...

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CPNE1 mediates glycolysis and metastasis of breast cancer through activation of PI3K/AKT/HIF-1α signaling

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