Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

You, Baiyang;Liu, Yanbo;Chen, Jia;Huang, Xiao;Peng, Huihui;...

通讯作者：

Shi, Ruizheng;Zhang, Guogang

作者机构：

[Xu, Qian; Peng, Huihui; Liu, Yanbo; Zhang, Kai; Liu, Zhaoya; Huang, Xiao; Shi, Ruizheng; Zhang, Guogang; You, Baiyang] Cent S Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Hunan, Peoples R China.

[Chen, Jia] Cent S Univ, Xiangya Nursing Sch, Dept Humanist Nursing, Changsha 410008, Hunan, Peoples R China.

[Tang, Yixin] Univ South China, Affiliated Hosp 1, Dept Cardiovasc Med, Hengyang 421001, Peoples R China.

[Li, Xiaohui] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Cheng, Guangjie] Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA.

通讯机构：

[Shi, RZ; Zhang, GG] C

Cent S Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

*Hypoxia;*NF-kappaB;*Pulmonary artery smooth muscle cells;*Pulmonary vascular remodelling;*Vascular peroxidase 1

期刊：

Cardiovascular Research

ISSN：

0008-6363

年：

2018

卷：

114

期：

页码：

188-199

DOI：

10.1093/cvr/cvx234

基金类别：

This work was supported by grants from the National Nature Science Foundation of China (Nos 81570453 and 81102440 to S.R.Z.); the National Nature Science Foundation of China (No. 81170261 to Z.G.G.); the National Basic Research Program of China (973 Program) (No. 2014CB542402); the Postdoctoral Fund of China (No. 2013M542143); and the Hunan Provincial Natural Science Fund Subject (No. 2016JJ2159).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Reactive oxygen species (ROS) play essential roles in the pulmonary vascular remodelling associated with hypoxiainduced pulmonary hypertension (PH). Vascular peroxidase 1 (VPO1) is a newly identified haeme-containing peroxidase that accelerates oxidative stress development in the vasculature. This study aimed to determine the potential role of VPO1 in hypoxia-induced PH-related vascular remodelling. The vascular morphology and VPO1 expression were assessed in the pulmonary arteries of Sprague-Dawley (SD) rats. Nicotinamide adenine dinucleotide ...

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Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration

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