Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration

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成果类型：

期刊论文

作者：

You, Baiyang;Liu, Yanbo;Chen, Jia;Huang, Xiao;Peng, Huihui;...

通讯作者：

Shi, Ruizheng;Zhang, Guogang

作者机构：

[Xu, Qian; Peng, Huihui; Liu, Yanbo; Zhang, Kai; Liu, Zhaoya; Huang, Xiao; Shi, Ruizheng; Zhang, Guogang; You, Baiyang] Cent S Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Hunan, Peoples R China.

[Chen, Jia] Cent S Univ, Xiangya Nursing Sch, Dept Humanist Nursing, Changsha 410008, Hunan, Peoples R China.

[Tang, Yixin] Univ South China, Affiliated Hosp 1, Dept Cardiovasc Med, Hengyang 421001, Peoples R China.

[Li, Xiaohui] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Cheng, Guangjie] Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA.

通讯机构：

[Shi, RZ; Zhang, GG] C

Cent S Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

*Hypoxia;*NF-kappaB;*Pulmonary artery smooth muscle cells;*Pulmonary vascular remodelling;*Vascular peroxidase 1

期刊：

Cardiovascular Research

ISSN：

0008-6363

年：

2018

卷：

114

期：

页码：

188-199

DOI：

10.1093/cvr/cvx234

基金类别：

This work was supported by grants from the National Nature Science Foundation of China (Nos 81570453 and 81102440 to S.R.Z.); the National Nature Science Foundation of China (No. 81170261 to Z.G.G.); the National Basic Research Program of China (973 Program) (No. 2014CB542402); the Postdoctoral Fund of China (No. 2013M542143); and the Hunan Provincial Natural Science Fund Subject (No. 2016JJ2159).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

AbstractAimsReactive oxygen species (ROS) play essential roles in the pulmonary vascular remodelling associated with hypoxia-induced pulmonary hypertension (PH). Vascular peroxidase 1 (VPO1) is a newly identified haeme-containing peroxidase that accelerates oxidative stress development in the vasculature. This study aimed to determine the potential role of VPO1 in hypoxia-induced PH-related vascular remodelling.Methods and resultsThe vascular morphology and VPO1 expression were assessed in the pulmonary arteries of Sprague–Dawley (SD) rats. Ni...

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Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration

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