期刊论文

Li, Lanfang;Chen, Linxi

英文

Clinica Chimica Acta

0009-8981

2018

479

196-207

10.1016/j.cca.2018.01.032

This study is funded by grants from the National Natural Science Foundation of China ( 81670265 , 81470434 ), Hunan Province Cooperative Innovation Center for Molecular Target New Drugs Study (Hunan Provincial Education Department document) (Approval number: 2014-405 ). I am profoundly grateful to my supervisor, Linxi Chen, whose illuminating instruction and expert advice have guided me through every step of my writing of this thesis. They gave me lots of inspirations and encouragement.

本校为第一且通讯机构

The P2X7 purinergic receptor, a calcium permeable cationic channel, is activated by extracellular ATP. Most studies show that P2X7 receptor plays an important role in the nervous system diseases, immune response, osteoporosis and cancer. Mounting evidence indicates that P2X7 receptor is also associated with cardiovascular disease. For example, the P2X7 receptor activated by ATP can attenuate myocardial ischemia-reperfusion injury. By contrast, inhibition of P2X7 receptor decreases arrhythmia after myocardial infarction, prolongs cardiac survival after a long term heart transplant, alleviates t...