Deuterium-depleted water (DDW) inhibits the proliferation and migration of nasopharyngeal carcinoma cells in vitro

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成果类型：

期刊论文

作者：

Wang, Hongqiang;Zhu, Baohua;He, Zhiwei;Fu, Hui;Dai, Zhong;...

通讯作者：

Fang, Weiyi

作者机构：

[He, Zhiwei; Wang, Hongqiang; Li, Binbin; Huang, Guoliang; Yang, Huiling; Zhu, Baohua; Dai, Zhong; Qin, Dongyun; Zhang, Xiaoyan; Fu, Hui] Guangdong Med Coll, Sino Amer Canc Res Inst, Dongguan 523808, Peoples R China.

[Wang, Hongqiang; Yang, Huiling] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Fang, Weiyi] Southern Med Univ, Canc Res Inst, Guangzhou 510515, Guangdong, Peoples R China.

[Tian, Lu] Guangdong Pharmaceut Univ, Inst Mat Med, Guangzhou 510006, Guangdong, Peoples R China.

通讯机构：

[Fang, Weiyi] S

Southern Med Univ, Canc Res Inst, Guangzhou 510515, Guangdong, Peoples R China.

语种：

英文

关键词：

Cell proliferation;Deuterium-depleted water (DDW);NADPH:quinone oxidoreductase-1 (NQO1);Nasopharyngeal carcinoma cell (NPC);Preosteoblast cell

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2013

卷：

期：

页码：

489-496

DOI：

10.1016/j.biopha.2013.02.001

基金类别：

This work was supported by two grants from the National Natural Sciences Foundation of China (NO. 30971438 and NO. 81272334 ).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Recent studies have demonstrated that natural water that has 65% of the deuterium concentration depleted, can exhibit anti-tumor properties. However, the anti-tumor effects of DDW on various nasopharyngeal carcinoma (NPC) cells have not previously been reported. In the present study, NPC cell lines and normal preosteoblast MC3T3-E1 cells were grown in RPMI1640 media containing different deuterium concentrations (50-150. ppm). The effects of DDW on the proliferation and migration of NPC and MC3T3-E1 cells were investigated using the MTT, plate c...

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Deuterium-depleted water (DDW) inhibits the proliferation and migration of nasopharyngeal carcinoma cells in vitro

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