NIR-activated water-soluble molecular probe based on Cu(ii) ion quenching mechanisms and substituted strategies: For in vitro/in vivo H2S detection

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成果类型：

期刊论文

作者：

Yu, Wanying;Wu, Juan;Wang, Feirong;Tan, Xiaofeng;Liu, Yu;...

通讯作者：

Li, Le;Yang, Qinglai;Wu, GL

作者机构：

[Wang, Feirong; Liu, Yu; Li, Le; Yang, Qinglai; Wu, Gui-long; Wu, GL; Yang, QL; Yu, Wanying; Tan, Xiaofeng; Tan, Senyou] Univ South China, Dept Publ Hlth Lab Sci, Sch Publ Hlth, Affiliated Hosp 1,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Wang, Feirong; Liu, Yu; Li, Le; Yang, Qinglai; Wu, Gui-long; Wu, GL; Yang, QL; Yu, Wanying; Tan, Xiaofeng; Tan, Senyou] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

[Yang, Qinglai; Wu, Gui-long; Tan, Xiaofeng] Univ South China, Canc Res Inst, Ctr Mol Imaging Probe, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Yang, Qinglai; Wu, Gui-long; Tan, Xiaofeng] Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China.

[Yang, Qinglai; Wu, Gui-long; Tan, Xiaofeng] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, L; Wu, GL ; Yang, QL] U

Univ South China, Dept Publ Hlth Lab Sci, Sch Publ Hlth, Affiliated Hosp 1,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

NIR;Activated Probe;Cu(ii) ion quenching;H2S detection

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2024

卷：

415

页码：

135875

DOI：

10.1016/j.snb.2024.135875

基金类别：

CRediT authorship contribution statement Wanying Yu: Writing – review & editing, Writing – original draft, Validation, Supervision, Software, Resources, Methodology, Investigation, acquisition, Formal analysis. Juan Wu: Validation, Supervision, Software, Resources, Project administration, Methodology. Feirong Wang: Validation, Project administration, Methodology, Investigation, Conceptualization. Xiaofeng Tan: Investigation, acquisition. Yu Liu: Resources, Project administration, Methodology. Le Li: Resources, Acknowledgments Q.Y. acknowledges financial support from the National Natural Science Foundation of China (22374065), the Science and Technology Innovation Program of Hunan Province “Huxiang Young Talents Plan” (2021RC3106), the Key Research and Development Program of Hunan Province, China (2022SK2053), and the Outstanding Youth Foundation of Hunan Province (2024JJ2047). G-L W. thanks the Natural Science Foundation of Hunan Province of China (2024JJ6374) for funding support. L. L. acknowledges financial

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Human health, environmental contamination, and food safety are tightly associated with hydrogen sulfide (H2S). The safe and highly sensitive monitoring of H2S in tissues, organs, and blood has presented ongoing challenges. Herein, a novel near-infrared (NIR)-activated water-soluble molecular probe, denoted as IR820-TPY-Cu was developed for detecting hydrogen sulfide. This probe is built upon the fluorescent molecule IR820, a derivative of Indocyanine green (ICG). Upon reacting with H2S, IR820-TPY-Cu exhibits active fluorescence (670-750 nm), which is attributed to the Cu (II) ion quenching mec...

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NIR-activated water-soluble molecular probe based on Cu(ii) ion quenching mechanisms and substituted strategies: For in vitro/in vivo H2S detection

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