Study on the effects of Mogroside V in inhibiting NLRP3-mediated granulosa cell pyroptosis and insulin resistance to improve PCOS

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成果类型：

期刊论文

作者：

Yang, Wenqin;Ma, Yujie;Wu, Yafei;Lei, Xiaocan;Zhang, Jing;...

通讯作者：

Li, MX;Zhang, J

作者机构：

[Lei, Xiaocan; Li, Meixiang; Wu, Yafei; Yang, Wenqin] Univ South China, Affiliated Hosp 1, Gynecol & Obstet & Reprod Med Ctr, Sch Basic Med Sci,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Ma, Yujie] Cent Hosp Shaoyang, Reprod Med Ctr, Shaoyang, Hunan, Peoples R China.

[Zhang, Jing; Zhang, J] Univ South China, Gynecol & Obstet & Reprod Med Ctr, Sch Basic Med Sci, Hengyang Med Sch,Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, MX ; Zhang, J ] U

Univ South China, Affiliated Hosp 1, Gynecol & Obstet & Reprod Med Ctr, Sch Basic Med Sci,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Gynecol & Obstet & Reprod Med Ctr, Sch Basic Med Sci, Hengyang Med Sch,Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Polycystic Ovary Syndrome;Mogroside V;Pyroptosis;NLRP3;Granulosa Cells

期刊：

Journal of Ovarian Research

ISSN：

1757-2215

年：

2025

卷：

期：

页码：

1-18

DOI：

10.1186/s13048-024-01563-5

基金类别：

This work was supported by the Health Research Project of Hunan Provincial Health Commission (NO.B202305017305) the Hunan Province High-level Health Talent Major Scientific Research Project (No.20230569), the Natural Science Foundation of Hunan Province, China (No.2024JJ9373).

机构署名：

本校为第一且通讯机构

摘要：

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrinopathy in reproductive-aged women, contributing to 75% of infertility cases due to ovulatory dysfunction. The condition poses significant health and psychological challenges, making the study of its pathogenesis and treatment a research priority. This study investigates the effects of Mogroside V (MV) on PCOS, focusing on its anti-inflammatory and anti-insulin resistance properties. Forty-five female Sprague–Dawley rats were divided into three groups: control, PCOS model, and MV treatment...

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Study on the effects of Mogroside V in inhibiting NLRP3-mediated granulosa cell pyroptosis and insulin resistance to improve PCOS

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