Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo

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成果类型：

期刊论文

作者：

Xie, Wei;Li, Liang;Gong, Duo;Zhang, Min;Lv, Yun-Cheng;...

通讯作者：

Yin, Wei-Dong;Tang, Chao-Ke

作者机构：

[Gong, Duo; Zhang, Min; Tang, Chao-Ke; Zhao, Zhen-Wang; Li, Liang; Yin, Wei-Dong; Xie, Wei] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov,Med Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Lv, Yun-Cheng; Xie, Wei; Guo, Dong-ming] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China.

[Li, Liang] Univ South China, Dept Pathophysiol, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

[Zheng, Xi-Long] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Targets & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China.

通讯机构：

[Yin, WD; Tang, CK] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Kruppel-like factor;MicroRNA;Lipoprotein lipase;Inflammation;Macrophage;Atherosclerosis

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2019

卷：

289

页码：

143-161

DOI：

10.1016/j.atherosclerosis.2019.08.012

基金类别：

National Natural Science Foundation of China of ChinaNational Natural Science Foundation of China (NSFC) [81800386]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ2234, 2018JJ3453]; start-up funds for Ph.Ds in University of South China [2017XQD12, 2017XQD05]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

BACKGROUND AND AIMS: Kruppel-like factor 14 (KLF14) is known to play a role in atherosclerosis, but the underlying mechanisms are still largely unknown. The aim of our study was to explore the effects of KLF14 on lipid metabolism and inflammatory response, providing a potential target for lowering the risk of atherosclerosis-causing disease. METHODS AND RESULTS: mRNA and protein levels of KLF14 were significantly decreased in oxidized low-density lipoprotein (oxLDL)-treated macrophages and in the atherosclerotic lesion area. Chromatin immunoprecipitation (ChIP) and luciferase reporter gene ass...

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Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo

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