Tim-3 blockade enhances the clearance of Chlamydia psittaci in the lung by promoting a cell-mediated immune response

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成果类型：

期刊论文

作者：

Li, Zhenyu;Wang, Yan;Zheng, Kang;Lu, Xianzhou;He, Zhangping;...

通讯作者：

Li, Yumeng;Long, Dingxin

作者机构：

[Li, Zhenyu; Long, Dingxin] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.

[Li, Zhenyu; Zheng, Kang; He, Siqin; He, Zhangping] Univ South China, Inst Pathogen Biol, Sch Basic Med, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Wang, Yan] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Operating Room, Hengyang 421001, Peoples R China.

[Lu, Xianzhou] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Li, Yumeng] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Clin Lab Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Long, Dingxin] H

[Li, Yumeng] D

Department of Clinical Laboratory Medicine, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. Electronic address:

Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China. Electronic address:

语种：

英文

关键词：

Chlamydia psittaci;Immune response;Th1/Th17;Tim-3;Tregs

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2023

卷：

116

页码：

109780

DOI：

10.1016/j.intimp.2023.109780

基金类别：

This work was supported by the National Natural Science Foundation of China under Grant No. 81673227 , the Natural Science Foundation of Hunan Province under Grant No. 2022JJ40396 , 2021JJ40455 and 2020JJ4080 , and the Key Projects of the Hunan Provincial Department of Education (Grant No. 18A254 ).

机构署名：

本校为第一机构

院系归属：

医学院

公共卫生学院

摘要：

Chlamydia psittaci is remarkable at disrupting immunity and thus poses a great risk to the animal industry and public health. Immune inhibitory molecule upregulation and the accumulation of specialized cells play key roles in chlamydial clearance. It is clear that the T-cell immunoglobulin and mucin domain protein 3 receptor (Tim-3) can regulate effector T cells in infectious disease. However, the immunomodulatory effect of Tim-3 in C. psittaci infection remains unknown. Thus, the expression of Tim-3 in effector T cells and its immune regulator...

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Tim-3 blockade enhances the clearance of Chlamydia psittaci in the lung by promoting a cell-mediated immune response

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