Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Tianqing;Deng, Wenxu;Deng, Ying;Liu, Yao;Xiao, Sijie;...

通讯作者：

Liu, Y

作者机构：

[Zhang, Tianqing] First Peoples Hosp Changde City, Dept Cardiol, Changde 415003, Hunan, Peoples R China.

[Deng, Wenxu] Cent Hosp Hengyang, Hengyang 421001, Hunan, Peoples R China.

[Deng, Ying; He, Qi] Peoples Hosp Ningxiang City, Ningxiang, Hunan, Peoples R China.

[Liu, Yao] Univ South China, Affiliated Hosp 2, Hengyang Medcial Sch, Dept Cardiovasc Med, Hunan 421001, Peoples R China.

[Xiao, Sijie] First Peoples Hosp Changde City, Dept Ultrasound, Changde 415003, Peoples R China.

通讯机构：

[Liu, Y ] U

Univ South China, Affiliated Hosp 2, Hengyang Medcial Sch, Dept Cardiovasc Med, Hunan 421001, Peoples R China.

语种：

英文

关键词：

Myocardial ischemia-reperfusion injury;Programmed cell death;Traditional Chinese medicine

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2023

卷：

165

页码：

114706

DOI：

10.1016/j.biopha.2023.114706

基金类别：

Postgraduate Research and Innovation Project of Hunan Province [CX20221012]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Acute myocardial infarction remains the leading cause of death in humans. Timely restoration of blood perfusion to ischemic myocardium remains the most effective strategy in the treatment of acute myocardial infarction, which can significantly reduce morbidity and mortality. However, after restoration of blood flow and reperfusion, myocardial injury will aggravate and induce apoptosis of cardiomyocytes, a process called myocardial ischemia-reperfusion injury. Studies have shown that the loss and death of cardiomyocytes caused by oxidative stress, iron load, increased lipid peroxidation, inflam...

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Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment

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