Carbapenem-resistant Gram-negative bacteria exhibiting clinically undetected cefiderocol heteroresistance leads to treatment failure in a murine model of infection

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成果类型：

期刊论文

作者：

Liu, Hongwei;Zhou, Peng;Ma, Peng;Liu, Yaqin;Zhang, Yingfeng;...

通讯作者：

Yin, Weiguo;Li, Linhai;Lu, Y

作者机构：

[Li, Linhai; Liu, Hongwei; Yin, Weiguo; Ma, Peng; Lu, Yang; Liu, Yaqin; Zhou, Peng; Lu, Y; Xu, Lingqing; Yin, WG] Guangzhou Med Univ, Affiliated Qingyuan Hosp, Qingyuan Peoples Hosp, Qingyuan, Peoples R China.

[Zhang, Yingfeng] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang, Peoples R China.

[Li, Qiwei] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Lab Med, Guangzhou, Peoples R China.

[Yuan, Wenchang] Guangzhou Med Univ, KingMed Sch Lab Med, Guangzhou, Peoples R China.

通讯机构：

[Li, LH; Lu, Y ; Yin, WG] G

Guangzhou Med Univ, Affiliated Qingyuan Hosp, Qingyuan Peoples Hosp, Qingyuan, Peoples R China.

语种：

英文

关键词：

carbapenem resistance;cefiderocol;failure treatment;gene mutation;heteroresistance

期刊：

Frontiers in Microbiology

ISSN：

1664-302X

年：

2025

卷：

页码：

1496514

DOI：

10.3389/fmicb.2025.1496514

基金类别：

Medical Scientific Research Foundation of Guangdong Province, China [B2022198]; Administration of Traditional Chinese Medicine of Guangdong Province, China [20231408, 20232036]; Natural Science Foundation of Guangdong Province [2021A1515011360]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

INTRODUCTION: Carbapenem-resistant (CR) Gram-negative pathogens are classified by the WHO as critical threats due to limited therapeutic options. Cefiderocol (CFD), a novel siderophore cephalosporin, shows promise but remains unapproved in China. This study investigated the prevalence, clinical impact, and genetic mechanisms of cefiderocol heteroresistance (CFD-HR) in CR and ESBL-producing clinical isolates from China, where CFD remains unapproved. METHODS: A total of 407 CR and ESBL-producing isolates were analyzed. CFD-HR was identified by po...

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Carbapenem-resistant Gram-negative bacteria exhibiting clinically undetected cefiderocol heteroresistance leads to treatment failure in a murine model of infection

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