Hyaluronic Acid Unveiled: Exploring the Nanomechanics and Water Retention Properties at the Single-Molecule Level

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成果类型：

期刊论文

作者：

Yu, Miao;Guo, Xin;Zhang, Kai;Kang, Xiaomin;Zhang, Song;...

通讯作者：

Zhang, S;Qian, L

作者机构：

[Yu, Miao; Guo, Xin; Zhang, Kai] Sichuan Univ, Sch Mech Engn, Chengdu 610065, Peoples R China.

[Yu, Miao; Guo, Xin; Zhang, Kai] Sichuan Univ, Yibin Ind Technol Res Inst, Yibin 644000, Peoples R China.

[Kang, Xiaomin] Univ South China, Sch Mech Engn, Hengyang 421001, Peoples R China.

[Zhang, Song] Moutai Inst, Dept Food Sci & Engn, Renhuai 564502, Guizhou, Peoples R China.

[Qian, Lu; Qian, L] South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Peoples R China.

通讯机构：

[Zhang, S ] M

[Qian, L ] S

Moutai Inst, Dept Food Sci & Engn, Renhuai 564502, Guizhou, Peoples R China.

South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Peoples R China.

语种：

英文

期刊：

LANGMUIR

ISSN：

0743-7463

年：

2024

卷：

期：

页码：

2616-2623

DOI：

10.1021/acs.langmuir.3c02961

基金类别：

City-University Research Fund [22303057, 22003041]; National Natural Science Foundation of China [2022YFG0068]; Sichuan Province Science Technology Support Program [2022CDZG-11]; City-University Research Fund [2020TQ0103]; China Postdoctoral Science Foundation

机构署名：

本校为其他机构

院系归属：

机械工程学院

摘要：

Hyaluronic acid (HA), a vital glycosaminoglycan in living organisms, possesses remarkable mechanical and viscoelastic properties that have garnered significant attention in therapeutic, biomedical, and cosmetic applications. However, a comprehensive picture of the physicochemical and biocharacterization of HA at the single-molecule level remains elusive. In this work, atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation were used to investigate the nanomechanics and water retention...

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Hyaluronic Acid Unveiled: Exploring the Nanomechanics and Water Retention Properties at the Single-Molecule Level

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