Evidence that ADAM17 mediates the protective action of CGRP against angiotensin II-induced inflammation in vascular smooth muscle cells

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成果类型：

期刊论文

作者：

Zeng, Si-yu*;Yang, Li;Hong, Chen-liang;Lu, Hui-qin;Yan, Qiu-jiang;...

通讯作者：

Zeng, Si-yu;Qin, Xu-ping

作者机构：

[Zeng, Si-yu; Lu, Hui-qin; Chen, Yan] Guangdong Second Prov Gen Hosp, Inst Drug Clin Trial, Guangzhou 510317, Guangdong, Peoples R China.

[Hong, Chen-liang; Yang, Li; Qin, Xu-ping] Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang 421001, Hunan, Peoples R China.

[Yan, Qiu-jiang] Guangzhou Med Univ, Affiliated Hosp 3, Dept Cardiac & Thorac Surg, Guangzhou 510000, Guangdong, Peoples R China.

通讯机构：

[Zeng, Si-yu] G

[Qin, Xu-ping] U

Guangdong Second Prov Gen Hosp, Inst Drug Clin Trial, Guangzhou 510317, Guangdong, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

2 (2 amino 3 methoxyphenyl)chromone;4 (3 chloroanilino) 6,7 dimethoxyquinazoline;angiotensin II;beta actin;calcitonin gene related peptide;calcitonin gene related peptide[8-37];epidermal growth factor receptor;interleukin 1beta;interleukin 6;messenger RNA;mitogen activated protein kinase 1;mitogen activated protein kinase 3;protein;small interfering RNA;tumor necrosis factor;tumor necrosis factor alpha converting enzyme;Adam17 protein, rat;angiotensin II;calcitonin gene related peptide;epidermal growth factor receptor;mitogen activated protein kinase 1;mitogen activated protein kinase 3;tumor necrosis factor alpha converting enzyme;animal cell;antiinflammatory activity;Article;cell protection;controlled study;cytokine production;drug efficacy;drug mechanism;evidence based practice;mRNA expression level;nonhuman;protein expression level;protein phosphorylation;rat;RNA interference;signal transduction;upregulation;vascular smooth muscle cell;vasculitis;animal;cell line;chemically induced;cytology;inflammation;metabolism;renin angiotensin aldosterone system;smooth muscle cell;vascular smooth muscle;ADAM17 Protein;Angiotensin II;Animals;Calcitonin Gene-Related Peptide;Cell Line;ErbB Receptors;Inflammation;Mitogen-Activated Protein Kinase 1;Mitogen-Activated Protein Kinase 3;Muscle, Smooth, Vascular;Myocytes, Smooth Muscle;Rats;Renin-Angiotensin System;RNA, Small Interfering

期刊：

Mediators of Inflammation

ISSN：

0962-9351

年：

2018

卷：

2018

页码：

2109352

DOI：

10.1155/2018/2109352

基金类别：

This work was supported by grants from Natural Science Foundation of Guangdong Province (no. 2015A030310076), Science and Technology Planning Project of Guangdong Province (no. 2016A020226005), Medical Scientific Research Foundation of Guangdong Province (no. A2014159), and Youth Foundation of the Guangdong Second Provincial General Hospital (no. YZ2015-008).

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Calcitonin gene-related peptide (CGRP) has a potent protective action on the cardiovascular system; however, little is known about the role of CGRP in angiotensin II-(Ang II-) induced inflammation of vascular smooth muscle cells (VSMCs). This study is aimed at determining the anti-inflammatory effect of CGRP in Ang II-treated VSMCs and whether a disintegrin and metalloproteinase 17 (ADAM17) modulates this protective action. Small interference RNA (siRNA) and inhibitors of CGRP, epidermal growth factor receptor (EGFR), and extracellular signal-r...

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Evidence that ADAM17 mediates the protective action of CGRP against angiotensin II-induced inflammation in vascular smooth muscle cells

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