National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81502850]; Natural Science Foundation of Hunan Province in ChinaNatural Science Foundation of Hunan Province [2015JJ2122]; Undergraduate inquiry learning and innovative experimental project in Hunan province [336]
机构署名：
本校为其他机构
院系归属：
公共卫生学院
摘要：
We rationally designed an ultrasensitive and label-free sensing platform for determination of cadmium (Cd). The sensing platform contains G-quadruplex-Cd(II) specific aptamer (GCDSA) constructed by incorporating G-rich sequence at the end of 5' and the critical domain of the Cd-4 aptamer. GCDSA designed act as both a special recognition sequence for Cd2+ and a signal DNAzyme. In absence of Cd2+, GCDSA may mainly exist in a random coil sequence. Upon addition of Cd2+, GCDSA could probably be induced to fold into a G-quadruplex structure. The gen...
