Autophagy is involved in the pathogenesis of experimental autoimmune neuritis in rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Shouhong;Chen, Xiong;Xue, Ruirui;Zhou, Qiaofeng;Hu, Pengju;...

通讯作者：

Tian, Shaowen

作者机构：

[Zhou, Shouhong; Zhu, Wenting; Dai, Tingting; Xue, Ruirui; Tian, Shaowen; Hu, Pengju; Ouyang, Xinping] Univ South China, Inst Neurosci, Sch Med, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Xiong] Cent S Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Hunan, Peoples R China.

[Zhou, Qiaofeng] Univ South China, Affiliated Hosp 1, Dept Pediat, Hengyang 421001, Hunan, Peoples R China.

[Tian, Shaowen] Univ South China, Dept Physiol, Sch Med, Hengyang 421001, Hunan, Peoples R China.

[Tian, Shaowen] Univ South China, Inst Neurosci, Sch Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tian, Shaowen] U

Univ South China, Dept Physiol, Sch Med, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Neurosci, Sch Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

autophagy;beclin-1;experimental autoimmune neuritis;light chain-3;p62

期刊：

NEUROREPORT

ISSN：

0959-4965

年：

2016

卷：

期：

页码：

337-344

DOI：

10.1097/WNR.0000000000000543

基金类别：

construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China); Zhengxiang Scholar Program of University of South China [2014-004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171281]; Outstanding Youth Fund of the Department of Education of Hunan Province [15B208]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Recent studies have shown that autophagy is involved in peripheral nervous system disease. However, the role of autophagy in the pathogenesis of experimental autoimmune neuritis (EAN) remains unclear. Therefore, EAN was induced by a subcutaneous injection into both hind footpads of synthetic neuritogenic P2(57-81) peptide in male Lewis rats. The clinical evaluation was completed using a 10-point scale method. The histological alteration of sciatic nerves was analyzed by hematoxylin and eosin and luxol fast blue staining. The ultrastructure of sciatic nerves was analyzed by transmission electro...

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Autophagy is involved in the pathogenesis of experimental autoimmune neuritis in rats

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