期刊论文

Xiao, S.;Cheng, Y.

英文

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

2296-634X

2022

10

852135

10.3389/fcell.2022.852135

This work was supported by the Hunan Province Postgraduate scientific Research Innovation Project (CX20210380), the general project of Health Commission of Hunan Province (202205012566), the Department of Science and Technology of Hunan Province (2020SK53607), the project of Hunan Provincial Natural Science Foundation (grant number 2021JJ31030), Hunan postgraduate teaching platform project (2019-39), postgraduate independent exploration and innovation project of Central South University (2021zzts1080) and Changsha Natural Science Foundation (kq2014261).

本校为其他机构

Minichromosome maintenance 2 (MCM2) is a member of the minichromosomal maintenance family of proteins that mainly regulates DNA replication and the cell cycle and is involved in regulating cancer cell proliferation in various cancers. Previous studies have reported that MCM2 plays a pivotal role in cell proliferation and cancer development. However, few articles have systematically reported the pathogenic roles of MCM2 across cancers. Therefore, the present pan-cancer study was conducted. Various computational tools were used to investigate the MCM2 expression level, genetic mutation rate, and...