MiR-124–3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor

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成果类型：

期刊论文

作者：

Tao, Jun;Xia, Lin-Zhen;Liang, Lingli;Chen, Yanjun;Wei, Dangheng;...

通讯作者：

Wang, Zuo

作者机构：

[Chen, Yanjun; Tao, Jun; Xia, Lin-Zhen; Liang, Lingli; Wang, Zuo; Wei, Dangheng] Univ South China, Hengyang Med Coll, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hunan Int Sci & Technol Cooperat Base Arterioscle, Hengyang, Hunan, Peoples R China.

[Meng, Jun] Univ South China, Affiliated Hosp 1, Funct Dept, Hengyang 421001, Hunan, Peoples R China.

[Wu, ShiYuan] YueYang Maternal Child Med Hlth Hosp, Hunan Prov Innovat Training Base Med Postgrad, Yueyang 416000, Hunan, Peoples R China.

通讯机构：

[Wang, Zuo] U

Univ South China, Hengyang Med Coll, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hunan Int Sci & Technol Cooperat Base Arterioscle, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

HTR8-S/Vneo;Placental growth factor;Preeclampsia;Reactive oxygen species;miR-124–3p

期刊：

Placenta

ISSN：

0143-4004

年：

2020

卷：

101

页码：

176-184

DOI：

10.1016/j.placenta.2020.08.011

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81970389]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

INTRODUCTION: MiR-124-3p is one of the aberrantly expressed miRNAs in the placentas of patients with preeclampsia (PE), a severe obstetric complication characterised by hypertension and proteinuria. This study aimed to investigate the role of miR-124-3p in the invasion, migration and death of trophoblast cells and explore the potential mechanisms. METHODS: MiR-124-3p expression in placental tissues was compared with that in normal placenta. HTR8/SVneo cells were then transfected with miR-124-3p mimics to examine cellular apoptosis, migration an...

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MiR-124–3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor

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