H2S improves myocardial fibrosis caused by hyperthyroidism by downregulating stat pathways and regulating mir-21 and mir-29a expression

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成果类型：

期刊论文

作者：

Tan, Wenting;Nie, Liangui;Tang, Fen;Liu, Shengquan;Long, Junrong;...

通讯作者：

Yang, Jun;Chu, Chun

作者机构：

[Nie, Liangui; Liu, Shengquan; Yang, Jun; Tang, Fen; Long, Junrong; Tan, Wenting] Univ South China, Affiliated Hosp 1, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

[Chu, Chun] Univ South China, Affiliated Hosp 2, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yang, Jun; Chu, Chun] U

Univ South China, Affiliated Hosp 1, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

H2S;hyperthyroid cardiomyopathy;STAT;miR-21;miR-29a

期刊：

International Journal of Clinical and Experimental Medicine

ISSN：

1940-5901

年：

2019

卷：

期：

页码：

5228-5238

基金类别：

National Natural Science Foundation of China, Hunan Provincial Graduate Research and Innovation Project; Science Foundation Project for Postgraduate student of the University of South China [81202830, 81270181, CK2018B635, 2018KYZ063]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Objective: The aim of this study was to explore the effects of H2S on myocardial fibrosis induced by hyperthyroxine and expression of STAT signal pathways, miR-21, and miR-29a in the myocardium. Methods: A total of 40 rats were selected and randomly stratified into 4 groups, including the control group (Control), HCM model group (Thy), H2S-intervention model group (Thy+H2S), and H2S-intervention normal group (H2S). Hyperthyroidism rat models were prepared by intraperitoneal injections of L-thyroxine. Rats in the control group received intraperitoneal injections of normal saline. NaHS solution ...

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H2S improves myocardial fibrosis caused by hyperthyroidism by downregulating stat pathways and regulating mir-21 and mir-29a expression

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