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CLDDI: A Novel Method for Predicting Drug-Drug Interaction Events Based on Graph Contrastive Learning

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成果类型:
会议论文
作者:
Xu, Rong;Luo, Lingyun;Liu, Zhiming;Ouyang, Chunping;Wan, Yaping
通讯作者:
Liu, Z
作者机构:
[Ouyang, Chunping; Liu, Zhiming; Xu, Rong; Wan, Yaping; Liu, Z; Luo, Lingyun] Univ South China, Sch Comp, Hengyang, Peoples R China.
通讯机构:
[Liu, Z ] U
Univ South China, Sch Comp, Hengyang, Peoples R China.
语种:
英文
关键词:
drug-drug interaction;prediction;deep learning;graph contrastive learning;adverse drug events
期刊:
2023 11TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, ICBCB
年:
2023
页码:
105-112
会议名称:
11th International Conference on Bioinformatics and Computational Biology (ICBCB)
会议时间:
APR 21-23, 2023
会议地点:
Hangzhou, PEOPLES R CHINA
会议主办单位:
[Xu, Rong;Luo, Lingyun;Liu, Zhiming;Ouyang, Chunping;Wan, Yaping] Univ South China, Sch Comp, Hengyang, Peoples R China.
出版地:
345 E 47TH ST, NEW YORK, NY 10017 USA
出版者:
IEEE
ISBN:
979-8-3503-9787-1
基金类别:
Natural Science Foundation of Hunan Province of China [2022JJ30495]
机构署名:
本校为第一且通讯机构
摘要:
Adverse drug-drug interactions (DDIs) may occur when drugs are combined to treat complex or comorbid diseases, which can result in adverse drug events, injury, and even death. Therefore, accurate prediction of potential DDI events is critical. Recently, automated computational methods such as deep learning are widely used for DDI events prediction. However, most of these methods only consider single information about the drug or rely on a large amount of label data, which easily leads to insufficient robustness and generalization ability. Accordingly, we proposed a novel end-to-end graph contr...

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