期刊论文

Oxidative Stress Induced by High-fructose Diet and its Effects on Lipid Metabolism of SD Rats

中文

中国慢性病预防与控制

1004-6194

2005

13

1

7-8

10.3969/j.issn.1004-6194.2005.01.003

本校为第一机构

目的探讨高果糖饲料诱导SD大鼠氧化应激和对其脂质代谢的影响.方法实验大鼠分为2组,分别用普通饲料和高果糖饲料喂养8周,检测大鼠空腹血糖(FBG)、血胰岛素(FSI)、血脂、总抗氧化力(T-AOC)、丙二醛(MDA)及超氧化物岐化酶(SOD)等.结果高果糖饲料组胰岛素敏感指数(ISI)低于普通饲料组(P＜0.01),甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)升高(分别为P＜0.01,P＜0.05和P＜0.01),高密度脂蛋白胆固醇(HDL-C)降低(P＜0.05),T-AOC、SOD活性降低(P＜0.01),MDA水平升高(P＜0.01).结论高果糖饲料可诱导SD大鼠产生氧化应激,引起脂质代谢紊乱.

Objective To study oxidative stress induced by high-fructose diet and its effects on lipid metabolism of SD rats. Methods The rats were divided into two groups, one fed with basic diet and the other with high-fructose diet. At the end of 8th week, their blood samples were collected and contents of FBS, FSI, blood lipids, T-AOC, MDA and SOD were determined and ISI was calculated. Results Compared with basic diet group, the ISI and the levels of HDLC and T-AOC and the activity of SOD in high-fructose diet group decreased significantly (P